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Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis

Received: 6 April 2016     Accepted: 18 April 2016     Published: 3 May 2016
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Abstract

Hemodialysis is a method that used to achieve the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of renal failure. However, this treatment may reduce the effectiveness of certain drugs. It is necessary to study the dialysance of quinine, a drug used in first intention for the treatment of severe malaria due to the fragility of uremic patients and the presence of malaria in endemic areas. This study has been conducted at the hemodialysis center of SAMU (Service d’Aide Médicale d’Urgence) in Abidjan Cocody. Twenty one (21) subjects with chronic renal failure aged of 24 to 50 years were enrolled. Two groups of subjects were formed. Each patient of the first group (9 subjects) received per person one tablet of 500 mg of quinine base (single dose) before the hemodialysis started. The second group (12 subjects) received in perfusion 5% glucose solution (250 mL) containing 10 mg.kg-1 of quinine base during 4 hours. The perfusion system and the hemodialysis system were conducted simultaneously. The concentrations of quinine in the tablet, the perfusion solution and the human blood were determined by a validated high performance liquid chromatography method. Quinine content in tablet and perfusion solution was in agreement with the manufacturer's specifications. The clearance of quinine was 23.67 mL.min-1. It appeared of this study that quinine fraction extracted did not require dose adjustment.

Published in Science Journal of Analytical Chemistry (Volume 4, Issue 3)
DOI 10.11648/j.sjac.20160403.12
Page(s) 26-29
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

HPLC, Antimalarial, Quinine, Hemodialysis, Chronic Renal Failure

References
[1] B. Ouattara, O. Kra, H. Yao, K. Kadjo, E. K. Niamkey, Particularités de l’insuffisance rénale chronique chez des patients adultes noirs hospitalisés dans le service de médecine interne du CHU de Treichville, Néphrol. & Thér. 7 (2011) 531-534.
[2] D. A. Gnionsahé, W. M. Tia, P. N. A. Coulibaly, D. A. Lagou, C. Ackoundou-N’guessan, M. A. Moudachirou, Circonstances de démarrage de la dialyse en Afrique : expérience d’un hôpital public en Côte d’Ivoire, Rev. Int. Sc. Méd. 16 (2014) 44-46.
[3] World Health Organization, Severe falciparum malaria, Trans. R. Soc.Trop. Med. Hyg. 94 (2000) supplement 1.
[4] Ministère chargé de la santé en Côte d’Ivoire, Programme National de lutte contre le Paludisme (2004) 1-33.
[5] L. Roy, M. Leblanc, P. Bannon, J-P. Villeneuve, Quinine pharmacokinetics in chronic hemodialysis patients, Br. J. Clin. Pharmacol. 52 (2002) 604-609.
[6] V. F. Samanidou, E. N. Evaggelopoulou, I. N. Papadoyannis, Simultaneous determination of quinine and chloroquine anti-malarial agents in pharmaceuticals and biological fluids by HPLC and fluorescence detection, J. Pharm. Biomed. Anal. 38 (2005) 21-28.
[7] A. M. Sharma, F. Keller, M. Boeckh, J. Heitz, K. Borner, Quinine dosage in severe malaria with renal failure necessitating hemodialysis, Eur. J. Clin. Pharmacol. 36 (1989) 535-536.
[8] D. V. McCalley, Analysis of the Cinchona al-kaloids by high-performance liquid chromatography and other separation techniques, J. Chromatogr. A 967 (2002) 1-19.
[9] S. Ahuja, Chromatography and separation science, Amsterdam; Boston: Academic Press, 2003.
[10] K. Sukontason, J. Karbwang, W. Rimchala, T. Tin, K. Na-Bangchang, V. Banmairuroi, D. Bunnag, Plasma quinine concentrations in falciparum malaria with acute renal failure, Trop. Med. Int. Health 1 (1996) 236-242.
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  • APA Style

    Christophe N’cho Amin, Philippe André Sawa Kpaibé, Nicaise François Bony, Gildas Komenan Gbassi, Michèle Aké, et al. (2016). Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis. Science Journal of Analytical Chemistry, 4(3), 26-29. https://doi.org/10.11648/j.sjac.20160403.12

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    ACS Style

    Christophe N’cho Amin; Philippe André Sawa Kpaibé; Nicaise François Bony; Gildas Komenan Gbassi; Michèle Aké, et al. Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis. Sci. J. Anal. Chem. 2016, 4(3), 26-29. doi: 10.11648/j.sjac.20160403.12

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    AMA Style

    Christophe N’cho Amin, Philippe André Sawa Kpaibé, Nicaise François Bony, Gildas Komenan Gbassi, Michèle Aké, et al. Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis. Sci J Anal Chem. 2016;4(3):26-29. doi: 10.11648/j.sjac.20160403.12

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  • @article{10.11648/j.sjac.20160403.12,
      author = {Christophe N’cho Amin and Philippe André Sawa Kpaibé and Nicaise François Bony and Gildas Komenan Gbassi and Michèle Aké and Apollinaire Gnionsahé and Eugène Atindehou},
      title = {Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis},
      journal = {Science Journal of Analytical Chemistry},
      volume = {4},
      number = {3},
      pages = {26-29},
      doi = {10.11648/j.sjac.20160403.12},
      url = {https://doi.org/10.11648/j.sjac.20160403.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20160403.12},
      abstract = {Hemodialysis is a method that used to achieve the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of renal failure. However, this treatment may reduce the effectiveness of certain drugs. It is necessary to study the dialysance of quinine, a drug used in first intention for the treatment of severe malaria due to the fragility of uremic patients and the presence of malaria in endemic areas. This study has been conducted at the hemodialysis center of SAMU (Service d’Aide Médicale d’Urgence) in Abidjan Cocody. Twenty one (21) subjects with chronic renal failure aged of 24 to 50 years were enrolled. Two groups of subjects were formed. Each patient of the first group (9 subjects) received per person one tablet of 500 mg of quinine base (single dose) before the hemodialysis started. The second group (12 subjects) received in perfusion 5% glucose solution (250 mL) containing 10 mg.kg-1 of quinine base during 4 hours. The perfusion system and the hemodialysis system were conducted simultaneously. The concentrations of quinine in the tablet, the perfusion solution and the human blood were determined by a validated high performance liquid chromatography method. Quinine content in tablet and perfusion solution was in agreement with the manufacturer's specifications. The clearance of quinine was 23.67 mL.min-1. It appeared of this study that quinine fraction extracted did not require dose adjustment.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Determination of Quinine Clearance in Chronic Renal Failure During Haemodialysis
    AU  - Christophe N’cho Amin
    AU  - Philippe André Sawa Kpaibé
    AU  - Nicaise François Bony
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    AU  - Michèle Aké
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    T2  - Science Journal of Analytical Chemistry
    JF  - Science Journal of Analytical Chemistry
    JO  - Science Journal of Analytical Chemistry
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    EP  - 29
    PB  - Science Publishing Group
    SN  - 2376-8053
    UR  - https://doi.org/10.11648/j.sjac.20160403.12
    AB  - Hemodialysis is a method that used to achieve the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of renal failure. However, this treatment may reduce the effectiveness of certain drugs. It is necessary to study the dialysance of quinine, a drug used in first intention for the treatment of severe malaria due to the fragility of uremic patients and the presence of malaria in endemic areas. This study has been conducted at the hemodialysis center of SAMU (Service d’Aide Médicale d’Urgence) in Abidjan Cocody. Twenty one (21) subjects with chronic renal failure aged of 24 to 50 years were enrolled. Two groups of subjects were formed. Each patient of the first group (9 subjects) received per person one tablet of 500 mg of quinine base (single dose) before the hemodialysis started. The second group (12 subjects) received in perfusion 5% glucose solution (250 mL) containing 10 mg.kg-1 of quinine base during 4 hours. The perfusion system and the hemodialysis system were conducted simultaneously. The concentrations of quinine in the tablet, the perfusion solution and the human blood were determined by a validated high performance liquid chromatography method. Quinine content in tablet and perfusion solution was in agreement with the manufacturer's specifications. The clearance of quinine was 23.67 mL.min-1. It appeared of this study that quinine fraction extracted did not require dose adjustment.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphou?t-Boigny, Abidjan, C?te d’Ivoire

  • Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphou?t-Boigny, Abidjan, C?te d’Ivoire

  • Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphou?t-Boigny, Abidjan, C?te d’Ivoire

  • Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphou?t-Boigny, Abidjan, C?te d’Ivoire

  • Hemodialysis Centre, University Hospital of Cocody, Abidjan, C?te d’Ivoire

  • Department of Analytical Chemistry, General Chemistry and Inorganic Chemistry, Faculty of Pharmaceutical and Biological Sciences, University of Félix Houphou?t-Boigny, Abidjan, C?te d’Ivoire

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