Research Article
Sustainable Spectrophotometric Quantification of Lansoprazole Through Mixed Hydrotropy Approach
Ketan Soni*
,
Kavita Sharma
Issue:
Volume 12, Issue 3, September 2024
Pages:
33-37
Received:
30 August 2024
Accepted:
18 September 2024
Published:
18 November 2024
Abstract: Solubility is the property of a substance to dissolve in or form a homogeneous mixture with another substance. One of the most common problems associated with making a solution is poor solubility. There are many drugs that are sparingly soluble or insoluble in water, and lansoprazole is one of them. Aqueous solubility of lansoprazole is 0.05 mg/ml at room temperature. The current study aims to improve lansoprazole solubility using a mixed hydrotropy method. The purpose of the mixed hydrotropic solubilization approach is to increase the solubility of weakly water-soluble drugs in hydrotropic agent blends. To avoid the use of organic solvents, the mixed hydrotropy idea may be a good option. In this current research attempt, a novel method for spectrophotometric estimation of lansoprazole using a mixed solvent blend (containing 10% SC and 20% SB) as the solvent was developed. By observing the absorbances of the drug's standard solutions, the calibration curve for lansoprazole was drawn. The absorbances were measured at 275 nm compared to the corresponding reagent blanks. The percent label claims were found to be very near to 100, showing that the proposed approach is accurate. The suggested method estimates percent recoveries to be near 100 with significantly low percentage deviation and standard error values. As a result, the proposed process is simple, safe, and precise, and it does not require the use of harmful chemical solvents.
Abstract: Solubility is the property of a substance to dissolve in or form a homogeneous mixture with another substance. One of the most common problems associated with making a solution is poor solubility. There are many drugs that are sparingly soluble or insoluble in water, and lansoprazole is one of them. Aqueous solubility of lansoprazole is 0.05 mg/ml ...
Show More
Research Article
Efficiency of Two Laterites in Cyanide Removal from Aqueous Solutions: Equilibrium and Kinetic Studies
Djakaridja Sory,
Yacouba Sanou*,
Raymond Kaboré,
Samuel Paré
Issue:
Volume 12, Issue 3, September 2024
Pages:
38-45
Received:
17 October 2024
Accepted:
27 November 2024
Published:
16 December 2024
DOI:
10.11648/j.sjac.20241203.12
Downloads:
Views:
Abstract: In the dynamic of drinking water supply in rural populations, water pollution by cyanide is one of challenges that impacts the process in the mining areas of Burkina Faso. The objective of this work was to assess the efficiency of laterite soils to remove cyanide from water. To do this, two laterites were prepared and characterized by spectroscopic and analytical techniques to serve as adsorbent. The cyanide removal was carried out using batch experiments with cyanide aqueous solutions. The characterization of laterites using analytical techniques showed a specific surface area of 42.39 and 24.55 m2.g-1. The crystalline phases were mainly kaolinite, goethite, hematite, quartz, and alumina. The optimization of the operating parameters indicated a strong influence of operating conditions on the adsorption process. Indeed, the optimum stirring speed was 150 rpm corresponding to an adsorption capacity of 0.14 and 0.34 mg/g using raw (LB) and treated (LT) laterites, respectively. By assessing the influence of the contact time, the adsorption capacities were 0.35 and 0.19 mg.g-1 at 40 and 75 min respectively using LT and LB corresponding to a treatment rate of 53% and 28%. The optimal doses were 28 and 45 g.L-1 at the optimal temperature of 30°C using LB and LT. Results concluded the efficiency of treated laterite comparatively to the raw laterite. The isotherm modelling concluded on Freundlich isotherm indicating a multilayer adsorption following a pseudo-second order kinetic. Therefore, these laterites would be good filters for the treatment of cyanide enriched waters and other heavy metals in dynamic experiments.
Abstract: In the dynamic of drinking water supply in rural populations, water pollution by cyanide is one of challenges that impacts the process in the mining areas of Burkina Faso. The objective of this work was to assess the efficiency of laterite soils to remove cyanide from water. To do this, two laterites were prepared and characterized by spectroscopic...
Show More
