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Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode

Received: 1 July 2019     Accepted: 12 August 2019     Published: 25 November 2019
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Abstract

Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.

Published in Science Journal of Analytical Chemistry (Volume 7, Issue 5)
DOI 10.11648/j.sjac.20190705.11
Page(s) 92-97
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Tripelennamine Hydrochloride, Glassy Carbon Electrode, Detection Limit, Calibration Plot

References
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  • APA Style

    Jayant Ira Gowda, Rohini Manohar Hanabaratti, Sharanappa Thotappa Nandibewoor. (2019). Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Science Journal of Analytical Chemistry, 7(5), 92-97. https://doi.org/10.11648/j.sjac.20190705.11

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    ACS Style

    Jayant Ira Gowda; Rohini Manohar Hanabaratti; Sharanappa Thotappa Nandibewoor. Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Sci. J. Anal. Chem. 2019, 7(5), 92-97. doi: 10.11648/j.sjac.20190705.11

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    AMA Style

    Jayant Ira Gowda, Rohini Manohar Hanabaratti, Sharanappa Thotappa Nandibewoor. Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Sci J Anal Chem. 2019;7(5):92-97. doi: 10.11648/j.sjac.20190705.11

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  • @article{10.11648/j.sjac.20190705.11,
      author = {Jayant Ira Gowda and Rohini Manohar Hanabaratti and Sharanappa Thotappa Nandibewoor},
      title = {Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode},
      journal = {Science Journal of Analytical Chemistry},
      volume = {7},
      number = {5},
      pages = {92-97},
      doi = {10.11648/j.sjac.20190705.11},
      url = {https://doi.org/10.11648/j.sjac.20190705.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20190705.11},
      abstract = {Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode
    AU  - Jayant Ira Gowda
    AU  - Rohini Manohar Hanabaratti
    AU  - Sharanappa Thotappa Nandibewoor
    Y1  - 2019/11/25
    PY  - 2019
    N1  - https://doi.org/10.11648/j.sjac.20190705.11
    DO  - 10.11648/j.sjac.20190705.11
    T2  - Science Journal of Analytical Chemistry
    JF  - Science Journal of Analytical Chemistry
    JO  - Science Journal of Analytical Chemistry
    SP  - 92
    EP  - 97
    PB  - Science Publishing Group
    SN  - 2376-8053
    UR  - https://doi.org/10.11648/j.sjac.20190705.11
    AB  - Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.
    VL  - 7
    IS  - 5
    ER  - 

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Author Information
  • Post Graduate Department of Studies in Chemistry, Parappa Channappa Jabin Science College, Hubballi, Karnataka, India

  • Department of Chemistry, Karnatak Science College, Dharwad, Karnataka, India

  • Post Graduate Department of Studies in Chemistry, Karnatak University, Dharwad, Karnataka, India

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