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Effects of Moringa oleifera Biochemical Constituents on Kidney, Liver and Brain of Wister Rats

Received: 18 March 2020     Accepted: 2 April 2020     Published: 31 December 2020
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Abstract

Medicinal plant have evolved over the centuries as essential parts of African civilization and are widely recognized today as representing its rich cultural and scientific heritage. The increasing demand for Medicinal plant products has renewed interest in the pharmaceutical industry in the production of herbal health care formulations, herbal-based cosmetic products, and herbal nutritional supplements. Thus, in addition to serving medical and cultural functions, Medicinal plants in Africa have economic importance. Global and national markets have been growing for medicinal herbs, and significant economic gains are being realized through the sale of medicinal plant products. The aim of this particular investigation was to observe the effects of Moringa oleifera 80% methanol leaf extract on the histological architecture of kidney, liver and brain tissues. Fifteen (15) rats were randomLy divided into three (3) with five rats per group. Rats were exposed to 2000 mg/kg, 1000 mg/kg and 500 mg/kg of Moringa oleifera extract per os (p.o) along with the control group that was placed on commercial diet. There was no observed mortality in all experimental rats but there is deleterious effect in brain, liver and kidney in those that were exposed to higher doses especially the 2000 mg/kg. It’s therefore concluded that higher dose of Moringa oleifera is toxic while moderate doses is safe to most vital organs especially brain, liver and kidney. There is need for further investigation to identify the phytochemical constituents that are responsible for the toxic effects.

Published in Science Journal of Analytical Chemistry (Volume 8, Issue 4)
DOI 10.11648/j.sjac.20200804.11
Page(s) 128-132
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Brain, Extract, Kidney, Liver, Moringa oleifera, Phytochemical Constituents, Rats

References
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Cite This Article
  • APA Style

    Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. (2020). Effects of Moringa oleifera Biochemical Constituents on Kidney, Liver and Brain of Wister Rats. Science Journal of Analytical Chemistry, 8(4), 128-132. https://doi.org/10.11648/j.sjac.20200804.11

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    ACS Style

    Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez, et al. Effects of Moringa oleifera Biochemical Constituents on Kidney, Liver and Brain of Wister Rats. Sci. J. Anal. Chem. 2020, 8(4), 128-132. doi: 10.11648/j.sjac.20200804.11

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    AMA Style

    Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. Effects of Moringa oleifera Biochemical Constituents on Kidney, Liver and Brain of Wister Rats. Sci J Anal Chem. 2020;8(4):128-132. doi: 10.11648/j.sjac.20200804.11

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  • @article{10.11648/j.sjac.20200804.11,
      author = {Ibrahim Maina Hassan and Bashir Saidu and Ja’afaru Abdullahi Ishaq and Ashiru Dahiru and Nafisat Abdulazeez and Halima Ibrahim Yusuf and Dahiru Hafiz Karofi and Nicholas Nathaniel Pilau and Adamu Abdul Abubakar and Bulama Ibrahim and Adama Musa Abdullahi},
      title = {Effects of Moringa oleifera Biochemical Constituents on Kidney, Liver and Brain of Wister Rats},
      journal = {Science Journal of Analytical Chemistry},
      volume = {8},
      number = {4},
      pages = {128-132},
      doi = {10.11648/j.sjac.20200804.11},
      url = {https://doi.org/10.11648/j.sjac.20200804.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20200804.11},
      abstract = {Medicinal plant have evolved over the centuries as essential parts of African civilization and are widely recognized today as representing its rich cultural and scientific heritage. The increasing demand for Medicinal plant products has renewed interest in the pharmaceutical industry in the production of herbal health care formulations, herbal-based cosmetic products, and herbal nutritional supplements. Thus, in addition to serving medical and cultural functions, Medicinal plants in Africa have economic importance. Global and national markets have been growing for medicinal herbs, and significant economic gains are being realized through the sale of medicinal plant products. The aim of this particular investigation was to observe the effects of Moringa oleifera 80% methanol leaf extract on the histological architecture of kidney, liver and brain tissues. Fifteen (15) rats were randomLy divided into three (3) with five rats per group. Rats were exposed to 2000 mg/kg, 1000 mg/kg and 500 mg/kg of Moringa oleifera extract per os (p.o) along with the control group that was placed on commercial diet. There was no observed mortality in all experimental rats but there is deleterious effect in brain, liver and kidney in those that were exposed to higher doses especially the 2000 mg/kg. It’s therefore concluded that higher dose of Moringa oleifera is toxic while moderate doses is safe to most vital organs especially brain, liver and kidney. There is need for further investigation to identify the phytochemical constituents that are responsible for the toxic effects.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Effects of Moringa oleifera Biochemical Constituents on Kidney, Liver and Brain of Wister Rats
    AU  - Ibrahim Maina Hassan
    AU  - Bashir Saidu
    AU  - Ja’afaru Abdullahi Ishaq
    AU  - Ashiru Dahiru
    AU  - Nafisat Abdulazeez
    AU  - Halima Ibrahim Yusuf
    AU  - Dahiru Hafiz Karofi
    AU  - Nicholas Nathaniel Pilau
    AU  - Adamu Abdul Abubakar
    AU  - Bulama Ibrahim
    AU  - Adama Musa Abdullahi
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    PY  - 2020
    N1  - https://doi.org/10.11648/j.sjac.20200804.11
    DO  - 10.11648/j.sjac.20200804.11
    T2  - Science Journal of Analytical Chemistry
    JF  - Science Journal of Analytical Chemistry
    JO  - Science Journal of Analytical Chemistry
    SP  - 128
    EP  - 132
    PB  - Science Publishing Group
    SN  - 2376-8053
    UR  - https://doi.org/10.11648/j.sjac.20200804.11
    AB  - Medicinal plant have evolved over the centuries as essential parts of African civilization and are widely recognized today as representing its rich cultural and scientific heritage. The increasing demand for Medicinal plant products has renewed interest in the pharmaceutical industry in the production of herbal health care formulations, herbal-based cosmetic products, and herbal nutritional supplements. Thus, in addition to serving medical and cultural functions, Medicinal plants in Africa have economic importance. Global and national markets have been growing for medicinal herbs, and significant economic gains are being realized through the sale of medicinal plant products. The aim of this particular investigation was to observe the effects of Moringa oleifera 80% methanol leaf extract on the histological architecture of kidney, liver and brain tissues. Fifteen (15) rats were randomLy divided into three (3) with five rats per group. Rats were exposed to 2000 mg/kg, 1000 mg/kg and 500 mg/kg of Moringa oleifera extract per os (p.o) along with the control group that was placed on commercial diet. There was no observed mortality in all experimental rats but there is deleterious effect in brain, liver and kidney in those that were exposed to higher doses especially the 2000 mg/kg. It’s therefore concluded that higher dose of Moringa oleifera is toxic while moderate doses is safe to most vital organs especially brain, liver and kidney. There is need for further investigation to identify the phytochemical constituents that are responsible for the toxic effects.
    VL  - 8
    IS  - 4
    ER  - 

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Author Information
  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Medicine, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria

  • Department of Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria

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